Simulational Study of Cardiac Cell Contractility
نویسنده
چکیده
This model was developed for the study of excitationcontraction coupling for single cardiac cell. The basic assumptions are following: depolarization of cellular sarkolemma (membrane) rises inward calcium current Is , which rises the level of sarcoplasmatic calcium but also induces release of calcium from cisternal sarcoplasmic reticulum. These two basic sources increase the level of sarcoplasmic calcium so that calcium ions combine with regulatory protein troponin C and this enables combination of actin and myosin (i.e. crossbridge formation) and initiates contraction according to Huxley’s sliding filament theory. Properties of muscle are modelled by Hill (Maxwell) model. The simulation was done for both types of contraction: isometric and isotonic. Formation (disjunction) of crossbridge is supposed to be an active process utilizing energy.
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